Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th International Conference on Clinical & Experimental Dermatology San Antonio, USA.

Day 1 :

  • Track 1: Dermatological Diseases Track 2: Clinical Dermatology
Location: Texas - B
Speaker

Chair

Androniki Tosca

University of Crete, Greece

Speaker

Co-Chair

Farrokh Khosravi

Texas Institute of Dermatology, USA

Session Introduction

Farrokh Khosravi

Texas Institute of Dermatology, USA

Title: Glucocorticoid-induced osteoporosis: Whats new?

Time : 11:30- 11:50

Speaker
Biography:

Farrokh Khosravi has completed his fellowship of Rheumatology at the age of 38 years from Shiraz University. He is a part time assistant professor of Medicine. His field of interest is autoimmune skin disease and has published papers in field of Behcet's disease and Multicentric Reticulohistiocytosis in reputed journals and served as an reviewer for Journal of Hormozgan University of Medical Sciences.

Abstract:

Glucocorticoid-induced Osteoporosis (GIO) is one of the most challenging health issue in the aged population. Up to fifty percent of chronic glucocorticoid-treated patients will experience at least one osteoporosis related fracture. Any attempt to prevent GIO will significantly decrease patients morbidity and mortality. Novel drugs have been recently developed for preventing and/or treating GIO. New methods of detection, prevention and treatment of GIO will be discussed in this talk.

Karen E. Burke

Mt. Sinai Medical Center, USA

Title: Topical Antioxidants for Protection and Reversal of Environmental Stress

Time : 11:50-12:10

Speaker
Biography:

Karen Burke completed her Ph.D. (Biophysics, Cornell University), post-doctoral research ( Rockefeller University), and her MD and Dermatology Specialty (New York University). She is Assistant Clinical Professor (Mt. Sinai Medical Center) and in private practice. She has written more than 65 scientific publications, was Medical-Science Editor of the UN Diplomatic World Bulletin, and has been in Castle-Connolly’s Guide to Best Doctors (over 10 years). She is an Honorary Life Governor of the NY Academy of Sciences, on the Boards of NY Stem Cell Foundation, Parkinson’s Disease Foundation, Poly Prep Country Day School. She serves on the US FDA General and Plastic Surgery Device Advisory Panel.

Abstract:

Even with increased sunscreen application, full UV protection is rarely achieved and exposure to UVA as well as to UVB is potentially hazardous. Although UVA is less erythrogenic and carcinogenic than UVB, increasing evidence has proven that the skin suffers synergistic damage from UVA in combination with ubiquitous pollutants generated primarily by combustion of fossil fuels and cigarette smoking. Our laboratory demonstrated that benzo[a]pyrene (a major environmental pollutant) is a photosensitizer which generates reactive oxygen species upon exposure to UVA. Evidence of this damage and the mechanisms of synergy will be presented. Our research has further shown that topical antioxidants (vitamins C, E, and selenium) can not only protect, but also reverse this photo and environmental damage. Topical antioxidants can be absorbed by the skin to give a reservoir of protection that is not lost with swimming or perspiration. The challenge is to formulate each specific antioxidant with the correct molecular form so that it is stable and is indeed absorbed and can be metabolized by the skin to give effective activity. The requirements for topical vitamin E (d--tocopherol), vitamin C (L-ascorbic acid), and selenium (L-selenomethionine) will be discussed in detail and scientific substantiation of efficacy will be presented. Used in conjunction with sunscreen, not only protection from and reversal of photoaging, but also protection from skin cancer can be achieved.

Yuzhi Jiang

Shanghai Jiaotong University School of Medicine, China

Title: Three-dimensional insights into dermal tissue as a cue for cellular behavior

Time : 12:10-12:30

Speaker
Biography:

Jiang has completed his Ph.D. at the age of 36 years from the Second Military Medical University and Postdoctoral studies from Shanghai Jiaotong University School of Medicine. He is the Director of Department of Trauma Repair, Ruijin Hospital. He focuses his work on scar formation and tissue engineering. He has published more than 25 papers in journals.

Abstract:

Scar formation after injury is a big problem, which influences the skin function and esthetic appearances. Recent researchers have hinted many directions, one of which has shown that scar formation is related to the loss of integrity in dermal tissues. The structure of dermal tissue, which contains mostly collagen, is not only crucial for the mechanical stability of skin, but also acts as a dermal template, providing contact guidance for regulating cell behavior and restoring normal structure and function to skin that has been damaged by injury. These findings suggest a series of questions. How does contact guidance regulate cell behavior? What is the three-dimensional (3D) architecture of the dermal tissue? How does the native 3D architecture influence cell behavior in vivo? In this paper, combing our recent researches, we will review the recent advances in this field, that is, the phenomenon of contact guidance and explore the possible mechanism behind it.

Luna Tanrikulu

Zekai Tahir Burak Women’s Health Training and Research Hospital, Turkey

Title: Behcet’s disease: An overview and an update

Time : 13:15- 13:35

Speaker
Biography:

Luna Tanrıkulu has completed her medical degree in Hacettepe University Faculty of Medicine in 1998 and her dermatology residency in Ondokuz Mayıs University in 2002. She studied with Behcet’s disease patients for her thesis. She has been working in Zekai Tahir Burak’s Women Health Training and Research Hospital as a consultant dermatologist since 2003. She is aiming to complete her Ph.D. degree for "Basic Biotechnology" in Ankara University in 2015. Dr Tanrıkulu has published many interesting international and national papers since 1993.

Abstract:

Behcet's disease is an inflammatory disorder characterized by multiple system involvements. Oral ulcer is the major clinical finding and diagnostic criteria of the disease. As recurrent aphtous stomatitis affects 10% of the general population, we should keep in mind Behcet's disease in the differential diagnosis. Its prevalence is higher in the countries that ancient Silk Road had passed through once upon a time. The lower incidence seen in the people who migrated from these areas suggests not only genetical factors but also environmental factors play roles for the disease. There is no pathognomic or sensitive test for diagnosing Behcet's disease. Even histopathology is not useful. Diagnosis relies on clinical findings. According to International Study Group 1990, recurrent oral ulcers is mandatory for diagnosis and two of the other clinical findings (recurrent genital ulcers, eye lesions, skin lesions and positive pathergy test) must be present. Not only dermatologists and ophtalmologists, but also other specialists should take part in management of these patients because cardiovascular, neurological, gastrointestinal and musculoskeletal systems may all be involved. None of the treatments result in a cure of the disease. The aim of the treatment is to prevent irreversible damages during active early phase of the disease and to prevent exacerbations of mucocutaneous and joint involvement, usually not causing damage but affecting quality of life. The choice of the treatment mainly depends on the involvement place of the disease. European League Against Rheumatism (EULAR) published evidence based recommendations related to the eye, skin-mucosa disease and arthritis.

Ying Gu

Stony Brook University School of Dental Medicine, USA

Title: A novel chemically-modified curcumin

Time : 13:35 -13:55

Speaker
Biography:

Ying Gu has received her DDS and Ph.D degrees and resident studies from Stony Brook University School of Dental Medicine. She is currently an Assistant Professor in the Department of General Dentistry, Stony Brook University. She has published book chapters and papers in reputed journals and serving as the reviewer of multiple journals.

Abstract:

Accelerated aging in skin and impaired wound healing are among the severe complications in patients with diabetes. Prolonged or chronic inflammation in diabetes can result in elevated levels of pro-inflammatory cytokines, matrix metalloproteinases (MMPs) and other inflammatory mediators, which can lead to excessive degradation of newly-synthesized (non-crosslinked) collagen and pile-up of older cross-linked collagen (i.e., accelerated aging of the skin) and delayed wound healing. Curcumin has significant regulatory effects on inflammatory mediators, but is characterized by poor solubility and low bioactivity. Recently, we developed a series of chemically-modified-curcumins (CMCs) with increased solubility and zinc-binding activity, which greatly enhanced their therapeutic efficacy. In the current study, a novel tri-ketonic chemically-modified-curcumin, CMC2.24, (in contrast to the natural di-ketonic compound), demonstrated significant efficacy on skin atrophy and healing of standardized skin wounds in streptozotocin-induced diabetic rats. Topical application of 1% and 3% CMC 2.24 or systemic administration of CMC 2.24 significantly improved wound healing at 7, 14, and 30 days with no effect on the severe hyperglycemia, assessed by gross and histologic measurements. Densitometric analysis of gelatin zymograms revealed that MMP-9 was increased 125% in the diabetic wounds relative to non-diabetic wounds, and the topical and systemic effects of CMC2.24 on this proteinase showed the same pattern of efficacy as that seen for wound-healing.

Speaker
Biography:

Mazloom has completed his M.D. degree at Chicago Medical School and has done two years of residency training in orthopaedic surgery and currently a dermatology research fellow at CCF. He has participated in various basic science and clinical research projects, has published a book, a case report, and a book chapter.

Abstract:

Multicentric Reticulohistiocytosis (MR) is a rare systemic disease of unknown etiology characterized by mucocutaneous nodules and a progressive destructive arthritis.1, 2. A Strikingly high percentage of MR cases, 25-33%, are associated with the presence of an underlying malignancy, leading many authors to believe it represents a paraneoplastic syndrome.1, 3-5 However, due to the small overall number of cases, wide spectrum of associated malignancies, and observations that MR and the underlying malignancy do not always run parallel courses, this theory has remained debatable. We have systematically reviewed all reported cases of MR and found 55 cases associated with underlying malignancies. The mean age of patients was 55 years-old with a female-to-male ratio of 1.9. Although a wide variety of neoplasms were found in association with MR, gynecological (26%), breast (19%), respiratory (17%), and GI (11%) neoplasms composed the majority of cases. We examined the clinical, histopathological, and laboratory characteristics in addition to treatments and outcomes in these patients. A very high proportion of malignancies (76%) had metastasized by the time of diagnosis and accounted for a poor outcome in these patients with a 51% mortality rate. We believe that MR does represent a paraneoplastic phenomenon in a subset of patients; likely arising secondary to release of certain neoplasm-associated cytokines. Evidence also exists supporting osteoclastogenesis (both RANKL-dependent and independent mechanisms) as a potential mechanism for development of MR in these patients. It is possible that immune system-related genetic polymorphisms predispose certain individuals to develop MR in the setting of an underlying malignancy.

Deeptara Pathak Thapa

Nepal Medical College and Teaching Hospital, Nepal

Title: Porokeratotic eccrine ostial and dermal duct nevus

Time : 14:15 - 14:35

Speaker
Biography:

Deeptara Pathak Thapa, an assistant professor in Dermatology has been trained in BPKIHS, Nepal one of the finest medical college in South East Asia. She is the post graduate coordinator in Dermatology. She has published articles on interesting topics in peer reviewed journals and is a reviewer for many international journals including IJD. She has not only presented papers in national and international conferences but has also organized annual national conference as the scientific committee chairman. She is an active member of International societies like ICD, SARAD, DSI, IADVL and National Society, SODVELON. Her interest is in cosmetic and clinical dermatology.

Abstract:

Porokeratotic eccrine ostial dermal duct nevus (PEODDN) is a rare variant of porokeratosis with characteristic histological feature of cornoid lamella, which is a thin column of parakeratotic cells with an absent or decreased underlying granular layer and dyskeratotic cells that involve acrosyringia. The cause is still unknown. Recently it has been proposed that it is caused by somatic connexin 26 mutations. PEODDN clinically presents as either multiple linear punctuate pits with comedo like plugs on palms and soles or keratotic plaques and papules that resemble linear VEN on other areas. It can present at the time of birth or early childhood or can have a late onset. It is mostly asymptomatic but can be associated with pruritus, hyperhydrosis or anhidrosis. There is rare case reports of PEODDN associated with conditions like hyperthyroidism and sensory polyneuropathy, breast hypoplasia, Bowen's disease etc. Treatment options as mentioned in literature are few. CO2 laser was found effective in few cases. Recently combination of Erbium/CO2 laser has been found effective. It is a rare disease with few case reports till date. Biopsy is essential to make diagnosis and there is a need to identify new treatment options to do justice to this cosmetically disfiguring condition with psychological impact.

Tu Yuan-rong

The First Affiliated Hospital of Fujian Medical University, China

Title: Endoscopic thoracic sympathectomy for the treatment of palmar hyperhidrosis in 2000 cases

Time : 14:35 -14:55

Speaker
Biography:

Tu Yuan-rong has completed his M.D. at the age 24 from Fujian Medical University. He is the Chief of thoracic surgery department in first affiliated hospital of Fujian Medical University. He is board director of Fujian thoracic surgery society and board member of Chinese thoracic surgery. He has published more than 30 papers in reputed journals.

Abstract:

Retrospective study of 2000 cases palmar hyperhidrosis who underwent bilateral sympathectomy during Jan 2003 and Jun 2013. The curative results were compared between two groups: the T2 levels denervation (Group A, include T2 or T2-4) versus the T2 levels remained denervation (Group B, include T3 or T3-4 or T4). (1) All operations were successfully performed under thoracoscopic without conversion thoracotomy, severe morbidity and mortality. (2) All patients with palmar hyperhidrosis were completely dried immediate after surgery. (3) Accompanied axillary sweating and plantar sweating were improved in 84% and 71% patients respectively. (4) Side-effect of compensatory sweating were observed in 28% patients of group A and 13.4% of group B. (5) Endoscopic thoracic sympathectomy is an effective, safe and minimally invasive method for treatment of hyperhidrosis. (6) The diversity of surgical technique focus on following aspects: sympathectomy vs sympathictomy( i.e. resection vs ablation); sympathetic ganglion denervation vs sympathetic chain denervation; single level denervation vs multiple level denervation; which level is the best level to ablate; and how to deal with Kuntz fiber. (7) The method of T2 levels remaining denervation appears associated with less compensatory sweating.

Speaker
Biography:

Liu Yan-guo has completed his M.D. in 2000 and Ph.D. in 2005 from Health Science Center of Peking University. He is associated professor of thoracic surgery department in Peking University People's Hospital. He is board member of Chinese thoracic surgery. He has published 16 papers in reputed journals.

Abstract:

Sympathicotomy for palmar hyperhidrosis is safe and effective. T4 sympathicotomy was widely accepted for its least side effect of compensatory hyperhidrosis. But some patients resulted in mild moist hand after operation and some were unsatisfied. Some authors use intro-operative hand temperature change to guide procedure selection. This study aimed to investigate the association between intro-operative hand temperature change and the curative effect and to answer whether the above-mentioned guide is reasonable. From July 2011 to April 2012, 49 patients with palmar hyperhidrosis were treated with bilateral endoscopic sympathicotomy. The ipsilateral hand temperature of the patient was monitored and recorded before and 3min, 5min, 7min, 10min, 15min, 20min after the sympathetic trunk was transected. The maximum temperature elevation (Tmax) was used as the evaluation index. 49 patients had 98 sympathicotomies successfully with no mortality or morbidity. There were seventy-senven T4 sympathicotomies, fifteen T4+T5 sympathicotomies, and six T3 sympathicotomies. Tmax≤1°C in 49 hands(50.0%), 1~1.5°C in 17 hands(17.3%),>1.5°C in 32 hands(32.7%. 46 patients were followed up, and 3 patients were lost. The curative effect was satisfied in 86 hands(93.4%, and not satisfied in 6 hands(6.6%). In the 71 hands which received T4 sympathicotomy, The curative effect was satisfied in 67 hands(94.3%), and not satisfied in 4 hands(5.7%). In those unsatisfied hands, the Tmax were all less than 1°C. But in those hands with Tmax≤1°C, 32 out of 36 ( 88.9%)were satisfied. We conclude that intro-operative temperature change of the hand may have certain correlation with the curative effect. But the predictive value of temperature change for curative effect is insufficient. It is not reasonable to use it to guide procedure selection.

Speaker
Biography:

Dr. YunHai Yang from Zhejiang University, China. He is working in Department of General Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou.

Abstract:

Palmar hyperhidrosis is a common disease that causes intense significant for patients. Bilateral single-port thoracoscopic sympathectomy approach is an effective surgical treatment with high success rates and improvement in quality of life. In order to reduce surgical invasion and seek for better cosmetic results, we describe a novel protocol for thoracic sympathectomy in the treatment of palmar hyperhidrosis. Between January 2012 and September 2012, bilateral thoracic sympathectomy was performed through the anterior mediastinal pleura using the pleura videoscope with a single skin incision in 10 men and 6 women. A total of 16 patients were cured and the skin temperature increased by a mean of (2.7±0.6) 0C. The average operation time of was 67.9±15.8 min, with postoperative hospital stay of 1.9±0.6 days and operative bleeding of less than 20ml. All operations were successful with no severe complications or perioperative mortality. A 9.8±2.3 month (7-14 month) followup showed that palmar sweating improved in all patients and the effective rate was 100%. Single-incision bilateral thoracic sympathectomy through the anterior mediastinal pleura is an effective, feasible, safe and minimally invasive procedure with excellent cosmetic results.

Chuanjian Lu

Guangdong Provincial Hospital of Chinese Medicine, China

Title: Overview of chinese medicine for psoriasis vulgaris

Time : 15:35-15:55

Speaker
Biography:

Chuanjian Lu has completed her Ph.D from Guangzhou University of Chinese Medicine. She is the vice-president of Guangdong Provincial Hospital of Chinese Medicine. She serves as the professor and doctoral supervisor in Guangzhou university of Chinese Medicine in China and RMIT University in Australia. Her research major is Chinese herbal medicine for psoriasis. She has published more than 20 papers in reputed journals.

Abstract:

Psoriasis is a chronic, recurring skin condition with the manifestations of scaling and erythematous plaques. The global average prevalence of psoriasis was approximately 3-4%. Despite conventional therapies are effective, undesirable side effects bring a challenge to the long-term management of psoriasis. It is estimated that 50% of psoriasis sufferers utilized complementary and alternative medicine (CAM) in Europe and America. As component of CAM, Chinese medicine (CM) has a long history treating dermatological conditions with its unique and systemic theory. CM is characterized by holistic view, balance maintenance of Yin and Yang, treatment based on syndrome differentiation, which addresses individual treatment for each patient taking the impact of climate or geographic location into consideration. Apart from definite disease diagnosis according to international guidelines, syndrome type plays a crucial role in the individual treatment, which determines the Chinese herbal medicine (CHM) formula selection and efficacy. Following rigors methodology, four systematic reviews have been completed by our team, which suggest that CHM is effective for psoriasis vulgaris, or has add-on effect when combined with conventional therapies such as acitretin and phototherapy. YXBCM01 formula has been identified for psoriasis treatment in our clinical practice. Clinical trials and fundamental studies have been conducted in order to verify its efficacy, safety and pharmaceutical mechanism. In a case-control study, 61% of participants achieved PASI 50 after 12-week YXBCM01 treatment. Metabolomics changes have been observed among these participants post-treatment, which tend to be the status of health control. Mouse model study has shown that YXBCM01 may promote granular cells growth and inhibit proliferation of epidermis cells.

Anca Bordianu

University of Medicine and Pharmacy, Romania

Title: Mucocutaneous occurrences of the syphilis in pregnant and HIV positive women

Time : 16:30 -16:50

Speaker
Biography:

Anca Bordianu has completed her Ph.D. at the age of 30 years from "Carol Davila" University of Medicine and Pharmacy Bucharest, University that she graduated from in 2008. She currently works as a plastic surgeon at the Plastic and Reconstructive Surgery Department of the "Bagdasar-Arseni" Clinical Emergency Hospital Bucharest, Romania. She has published numerous papers in reputed journals and participated in national and international congresses and training courses. She is a member of Romanian Plastic and Reconstructive Surgery Society.

Abstract:

Introduction: "AIDS was the major epidemic of the 20th century, and remains the epidemic of the 21st century as well" thinks Prof. Jean-Francois Delfraissy, the director of the National Agency for Research on AIDS (ANRS). In the early 90's, over 50% of HIV-positive European children were living in Romania. Even today, most HIV/AIDS-positive people live in Romania- more than 7000 being children and adolescents. The purpose of my study is the correlation of the female mucocutaneous genital lesions with the clinical picture and the laboratory data, and the data correlation in pregnant women.
Material and methods: The methodological support of the paper is represented by various materials obtained from official sources and personal research. The epidemiological analysis of the HIV infection cases was made based on data with sanitary-epidemiological indicators selected from annual records, in the time period from 2005 to 2010. To determine the eligibility criteria for developing the epidemic process, in the study were used classical methods of retrospective statistical analysis of the annual and multiannual cases. I have used a series of blood tests, of which the best known and most used are the ELISA and the Western-Blot tests. The reaction of Western-Blot is very much used in present to confirm or disprove the result of the ELISA test regarding HIV (test for specific antibodies), which sometimes can be false positive.
Results and discussions: It is interesting to note that the infected mother's antibodies can be transmitted to the fetus and it may persist in the fetus's blood up to 18 months. A test performed during this period is positive, meaning it would indicate the presence of the infection although it is possible that the fetus was not infected (46 cases). Therefore, a positive HIV test is not significant, only after the age of 18 months. Of the total of 47 pregnant women under observation 32 of them had undergone caesarean section (the other ones quitted our service). The age of the pregnant women was between 21 and 36 years. Gestational age was, except for 2 cases (39 weeks), between 34-36 weeks. Female newborns weighed between 2100g-3300g, AI (Apgar Index) 8 or 9. We also detected injuries caused by syphilis in 8 of our cases.
Conclusion: The genital chancre (genital ulceration) caused by syphilis makes a person more vulnerable to sexually transmitting or acquiring the HIV infection. The existence of syphilis increases the risk of acquiring HIV by 2 to 5 times.

Deeptara Pathak Thapa

Nepal Medical College and Teaching Hospital, Nepal

Title: Lupus profundus: An Indian perspective

Time : 17:50 -18:10

Speaker
Biography:

Deeptara Pathak Thapa, an assistant professor in Dermatology has been trained in BPKIHS, Nepal one of the finest medical college in South East Asia. She is the post graduate coordinator in Dermatology. She has published articles on interesting topics in peer reviewed journals and is a reviewer for many international journals including IJD. She has not only presented papers in national and international conferences but has also organized annual national conference as the scientific committee chairman. She is an active member of International societies like ICD, SARAD, DSI, IADVL and National Society, SODVELON. Her interest is in cosmetic and clinical dermatology.

Abstract:

Porokeratotic eccrine ostial dermal duct nevus (PEODDN) is a rare variant of porokeratosis with characteristic histological feature of cornoid lamella, which is a thin column of parakeratotic cells with an absent or decreased underlying granular layer and dyskeratotic cells that involve acrosyringia. The cause is still unknown. Recently it has been proposed that it is caused by somatic connexin 26 mutations. PEODDN clinically presents as either multiple linear punctuate pits with comedo like plugs on palms and soles or keratotic plaques and papules that resemble linear VEN on other areas. It can present at the time of birth or early childhood or can have a late onset. It is mostly asymptomatic but can be associated with pruritus, hyperhydrosis or anhidrosis. There is rare case reports of PEODDN associated with conditions like hyperthyroidism and sensory polyneuropathy, breast hypoplasia, Bowen’s disease etc. Treatment options as mentioned in literature are few. CO2 laser was found effective in few cases. Recently combination of Erbium/CO2 laser has been found effective. It is a rare disease with few case reports till date. Biopsy is essential to make diagnosis and there is a need to identify new treatment options to do justice to this cosmetically disfiguring condition with psychological impact.